Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

Blog Article

Traumatic brain injury is a major cause of death and disability worldwide, affecting over 69 million individuals yearly.One-carbon Serrapeptase metabolism has been shown to have beneficial effects after brain damage, such as ischemic stroke.However, whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more investigation.

The aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain injury.PubMed, Web of Science, and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury outcomes.The search terms included combinations of the following words: traumatic brain injury, dietary supplementation, one-carbon metabolism, and B-vitamins.

The focus of each literature search was basic science data.The year of publication in the literature searches was not limited.Our analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recovery of animals with traumatic brain injury compared to controls.

However, this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delivery of vitamin supplementation post-traumatic brain injury.The details of supplementation post-traumatic brain injury need to be further investigated.Overall, we conclude that B-vitamin 407 supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model systems.

Further investigation in a clinical setting should be strongly considered in conjunction with current medical treatments for traumatic brain injury-affected individuals.